Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: Effects of the solvent dielectric
نویسندگان
چکیده
منابع مشابه
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.
Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and racemization of protein and peptide asparaginyl and aspartyl residues via succinimide intermediates. To understand the sequence dependence of these reactions, we measured the rate of succinimide formation in a series of synthetic peptides at pH 7.4. These peptides (Val-Tyr-Pro-X-Y-Ala) contained an internal ...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1993
ISSN: 0961-8368
DOI: 10.1002/pro.5560020305